Le Scienze Web News

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Heidelberg, 11 March 2013 - Genome of HeLa cells sequenced for the first time.

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Recent findings from the ICGEB Cellular Immunology lab published this week in JEM

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Every film and TV programme ever created - in a teacup

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A conference entitled 'Complex disease genetics for clinicians' will take place from 24 to 25 January 2013 in Hinxton, UK.

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Heidelberg, 5 December 2012 - We all have E.coli bacteria in our gut but each of us carries a version that is genetically slightly different. The same can be said of most gut microbes: our own gut metagenome, that is the sum of all the genomes of all our gut microbes, appears to be really specific to each of us, and to remain stable over time.

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Authors:
Amaya Alzu, Alessandra Brambati and Giordano Liberi (IFOM Foundation of Milan and Institute of Molecular Genetics of Italian National Research Council of Pavia).
Abstract
Mutations in Senataxin gene cause two severe neurodegenerative disorders, the Ataxia with oculomotor apraxia type 2 (AOA2) and the juvenile Amyotrophic Later Sclerosis 4 (ALS4). Our study published in Cell (Alzu et al., 2012) unravels a new molecular mechanism that involves Senataxin in preventing DNA damage due to the deleterious consequences of DNA replication-transcription conflicts.

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There is now overwhelming evidence that cell fate and development are determined not only by genetic factors, but also by the surrounding environment through external biophysical or biochemical stimuli. In particular, the response of cells to mechanical constraints strongly influences their biological functions.

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B cells are lymphocytes that play a key role in the immune response.

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The conference will bring together scientists from molecular cell biology, biochemistry, structural biology, biophysics and bioinformatics to explore the important field of protein-protein interactions.

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Cyanobacteria are a highly intriguing and versatile group of bacteria of enormous environmental and societal importance.

These oxygenic phototrophic bacteria transformed our environment in the past and contribute substantially to biogeochemical cycles in our contemporary life. As sustainable fuel producers and consumers of CO2, cyanobacteria can also help to shape the environment of the future.